Cognitive-Behavioral Therapy
Summary
Many studies have examined the effects of various types of CBT in treating obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, social phobia, specific phobia, and major depression
Many studies have examined the effects of various types of CBT in treating obsessive-compulsive disorder, post-traumatic stress disorder, panic disorder, social phobia, specific phobia, and major depression
Notable Studies:
1. Yoshimura et al., 2014
Take-home: Following 12 weeks of CBT, medial PFC and ventral anterior cingulate cortex (vACC) activity during self-referential processing among 23 depressive patients was increased for positive stimuli, whereas it was decreased for negative stimuli. Improvements in depressive symptoms were negatively correlated with vACC activity during self-referential processing of negative stimuli. These results suggest that CBT-related improvements in depressive symptoms are associated with changes in mPFC and vACC activation during self-referential processing of emotional stimuli.
2. Kircher et al., 2012
Take-home: Patients with panic disorder & agoraphobia who received CBT demonstrated reduced activation in the left inferior frontal gyrus in response to a conditioned stimulus compared to healthy controls. Reduction in activation after CBT correlated with reduction in agoraphobic symptoms.
3. Yamanishi et al., 2009
Take-home: Patients with OCD who responded to CBT showed a decrease in SPECT activity in the left medial prefrontal cortex and bilateral middle frontal gyri. Also, pre-treatment regional cerebral blood flow in the bilateral orbitofrontal cortex was significantly correlated with symptom improvement among responders.
Take-home: Following 12 weeks of CBT, medial PFC and ventral anterior cingulate cortex (vACC) activity during self-referential processing among 23 depressive patients was increased for positive stimuli, whereas it was decreased for negative stimuli. Improvements in depressive symptoms were negatively correlated with vACC activity during self-referential processing of negative stimuli. These results suggest that CBT-related improvements in depressive symptoms are associated with changes in mPFC and vACC activation during self-referential processing of emotional stimuli.
2. Kircher et al., 2012
Take-home: Patients with panic disorder & agoraphobia who received CBT demonstrated reduced activation in the left inferior frontal gyrus in response to a conditioned stimulus compared to healthy controls. Reduction in activation after CBT correlated with reduction in agoraphobic symptoms.
3. Yamanishi et al., 2009
Take-home: Patients with OCD who responded to CBT showed a decrease in SPECT activity in the left medial prefrontal cortex and bilateral middle frontal gyri. Also, pre-treatment regional cerebral blood flow in the bilateral orbitofrontal cortex was significantly correlated with symptom improvement among responders.